Antithrombotic effect of captopril and enalapril in old rats.
نویسندگان
چکیده
In the present study, we have shown considerably accelerated thrombosis in old rats in comparison with adult rats, which may be related to the impaired hemostatic balance in these animals. In old rats, captopril and enalapril caused a marked reduction of venous thrombus weight. The mechanism of antithrombotic action of these drugs seems to be dependent on the suppression of coagulation cascade and the enhancement of the fibrinolytic processes.
منابع مشابه
Antithrombotic effect of captopril and enalapril in young rats.
Angiotensin converting enzyme inhibitors (ACE-Is) are the main drugs used in the treatment of essential hypertension and congestive heart failure in adults. Recently, we have demonstrated the antithrombotic effect of captopril (CAP) and enalapril (ENA) in venous thrombosis model in adult rats. One might also suggest the beneficial effect of those drugs on hemostasis in young individuals. Two mo...
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ورودعنوان ژورنال:
- Pharmacological reports : PR
دوره 57 1 شماره
صفحات -
تاریخ انتشار 2005